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KMID : 1038620110290030147
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Radiation Oncology Journal
2011 Volume.29 No. 3 p.147 ~ p.155
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Radiation-induced brain injury: retrospective analysis of twelve pathologically proven cases
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Lee Dong-Soo
Yu Mi-Na
Jang Hong-Seok
Kim Yeon-Sil
Choi Byung-Ock
Kang Young-Nam
Yoon Sei-Chul
Lee Youn-Soo
Kim Dong-Chul
Hong Yong-Kil
Jeun Sin-Soo
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Abstract
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Purpose: This study was designed to determine the influencing factors and clinical course of pathologically proven cases of radiation-induced brain injury (RIBI).
Materials and Methods : The pathologic records of twelve patients were reviewed; these patients underwent surgery following radiotherapy due to disease progression found by follow-up imaging. However, they were fi nally diagnosed with RIBI. All patients had been treated with 3-dimensional conventional fractionated radiotherapy and/or radiosurgery for primary or metastatic brain tumors with or without chemotherapy. The histological distribution was as follows: two falx meningioma, six glioblastoma multiform (GBM), two anaplastic oligodendroglioma, one low grade oligodendroglioma, and one small cell lung cancer with brain metastasis.
Results: Radiation necrosis was noted in eight patients and the remaining four were diagnosed with radiation change. Gender (p = 0.061) and biologically equivalent dose (BED)3 (p = 0.084) were the only marginally infl uencing factors of radiation necrosis. Median time to RIBI was 7.3 months (range, 0.5 to 61 months). Three prolonged survivors with GBM were observed. In the subgroup analysis of high grade gliomas, RIBI that developed
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KEYWORD
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Radiation necrosis, Radiation injury, Chemoradiation, Brain tumor
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